The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF

被引：80

作者：

Prochasson, P ^{[1
]}

Florens, L ^{[1
]}

Swanson, SK ^{[1
]}

Washburn, MP ^{[1
]}

Workman, JL ^{[1
]}

机构：

[1] Stowers Inst Med Res, Kansas City, MO 64110 USA

来源：

GENES & DEVELOPMENT | 2005年 / 19卷 / 21期

关键词：

HIR; HPC; SWI/SNF; nucleosome remodeling; histone; HIRA;

D O I：

10.1101/gad.1341105

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The histone regulatory (HIR) and histone promoter control (HPC) repressor proteins regulate three of the four histone gene loci during the Saccharomyces cerevisiae cell cycle. Here, we demonstrate that Hir1, Hir2, Hir3, and Hpc2 proteins form a stable HIR repressor complex. The HIR complex promotes histone deposition onto DNA in vitro and constitutes a novel nucleosome assembly complex. The HIR complex stably binds to DNA and nucleosomes. Furthermore, HIR complex binding to nucleosomes forms a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Thus, the HIR complex is a novel nucleosome assembly complex which functions with SWI/SNF to regulate transcription.

引用

页码：2534 / 2539

页数：6

共 39 条

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