Silencing suppression by geminivirus proteins

被引：170

作者：

Bisaro, DM ^{[1
]}

机构：

[1] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA

[2] Ohio State Univ, Plant Biotechnol Ctr, Columbus, OH 43210 USA

来源：

VIROLOGY | 2006年 / 344卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.virol.2005.09.041

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

RNA silencing is an RNA-directed gene regulatory system that is present in a wide range of eukaryotes, and which functions as an antiviral defense in plants. Silencing pathways are complex and partially overlapping, but at least three basic classes can be distinguished: cytoplasmic RNA silencing (or post-transcriptional gene silencing; PTGS) mediated by small interfering RNAs (siRNAs), silencing mediated by microRNAs (miRNAs), and transcriptional gene silencing (TGS) mediated by siRNA-directed methylation of DNA and histone proteins. Recent advances in our understanding of different geminivirus silencing suppressors indicate that they can affect all three pathways, suggesting that multiple aspects of silencing impact geminivirus replication. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：158 / 168

页数：11

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