A novel anti-tumor agent, polyoxomolybdate induces apoptotic cell death in AsPC-1 human pancreatic cancer cells

被引：71

作者：

Ogata, A

Mitsui, S

Yanagie, H

Kasano, H

Hisa, T

Yamase, T

Eriguchi, M

机构：

[1] Univ Tokyo, Adv Sci & Technol Res Ctr, Dept Intellectual Property, Project Canc Metastasis Inhibit,Meguro Ku, Tokyo 1538904, Japan

[2] Tokyo Inst Technol, Chem Resources Lab, Midori Ku, Yokohama, Kanagawa 2268503, Japan

[3] Polytron Co Ltd, Kanazawa, Ishikawa 9200967, Japan

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2005年 / 59卷 / 05期

基金：

日本科学技术振兴机构;

关键词：

polyoxomolybdate; anti-tumor; apoptosis;

D O I：

10.1016/j.biopha.2004.11.008

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Anti-tumoral polyoxomolybdates have been investigated in the course of study of the medical application of polyoxometalates as discrete cluster anions of metal oxides. [NH3Pi](6)[Mo7O24]center dot 3H(2)O (PM-8) has been recognized as one of significantly anti-tumoral polyoxomolybdates. PM-8 inhibited the cell growth of human pancreatic cells (AsPC-1) depending on the dose. DNA ladder formation and DNA fragmentation were observed by Hoechst and TUNEL staining and flowcytometry analysis. The ratio of apoptotic cells were 29%, 35%, and 57% with treatment of PM-8 after 24, 48, and 72 h, respectively, which suggested that the anti-tumor activity of PM-8 results from the activation of the apoptotic pathway. Polyoxomolybdates provide promising, novel anti-tumor agent, especially for the treatment of cancers that are difficult to treat. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：240 / 244

页数：5

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