Cytoskeletal-associated proteins in the migration of cortical neurons

被引:23
作者
Bielas, SL
Gleeson, JG [1 ]
机构
[1] Univ Calif San Diego, Div Biol Sci, Neurobiol Sect, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
来源
JOURNAL OF NEUROBIOLOGY | 2004年 / 58卷 / 01期
关键词
neuronal migration; centrosome; nuclear migration; cortex development; cytoskeleton;
D O I
10.1002/neu.10280
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neuronal migration is a hallmark of cerebral cortical development as neurons born deep within the brain migrate to the surface in a highly choreographed process. The cytoskeleton extends throughout the cell, mediating the dramatic morphological changes that accompany migration. On a cellular level, proper migration is accompanied by polarization of the cytoskeleton and cellular contents and by dynamic reorganization that generates the force for cell locomotion. Genetic analyses of human brain malformations, as well as genetically engineered mouse mutants, have highlighted a number of cytoskeletal-associated proteins underlying these functions, which are necessary for proper cortical development. While these proteins are involved in diverse molecular mechanisms, disruption during development results in the ectopic placement of neurons in the cortex. We review key cytoskeletal events and the critical cytoskeletal-associated proteins involved in cortical neuronal migration. (C) 2003 Wiley Periodicals, Inc.
引用
收藏
页码:149 / 159
页数:11
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