The neurobiology of psychopathy

被引:80
作者
Glenn, Andrea L. [1 ]
Raine, Adrian [2 ,3 ,4 ]
机构
[1] Univ Penn, Dept Psychol, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Criminol, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
[4] Univ Penn, Dept Psychol, Philadelphia, PA 19104 USA
关键词
D O I
10.1016/j.psc.2008.03.004
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Numerous studies have tackled the complex challenge of understanding the neural Substrates of psychopathy, revealing that brain abnormalities exist on several levels and in several structures. As we discover more about complex neural networks, it becomes increasingly difficult to clarify how these systems interact with each other to produce the distinct pattern of behavioral and personality characteristics observed in psychopathy. The authors review the recent research on the neurobiology of psychopathy, beginning with molecular neuroscience work and progressing to the level of brain structures and their connectivity. Potential factors that may affect the development of brain impairments, as well as how some systems may be targeted for potential treatment, are discussed.
引用
收藏
页码:463 / +
页数:14
相关论文
共 84 条
[31]  
Harris G., 2006, HDB PSYCHOPATHY, P555
[32]   Behavioral evidence of prolonged interhemispheric transfer time among psychopathic offenders [J].
Hiatt, Kristina D. ;
Newman, Joseph P. .
NEUROPSYCHOLOGY, 2007, 21 (03) :313-318
[33]   CSF testosterone and 5-HIAA correlate with different types of aggressive behaviors [J].
Higley, JD ;
Mehlman, PT ;
Poland, RE ;
Taub, DM ;
Vickers, J ;
Suomi, SJ ;
Linnoila, M .
BIOLOGICAL PSYCHIATRY, 1996, 40 (11) :1067-1082
[34]   Inverse correlation between severity of psychopathic traits and serum cortisol levels in young adult violent male offenders [J].
Holi, M ;
Auvinen-Lintunen, L ;
Lindberg, N ;
Tani, P ;
Virkkunen, M .
PSYCHOPATHOLOGY, 2006, 39 (02) :102-104
[35]   A brain imaging (single photon emission computerized tomography) study of semantic and affective processing in psychopaths [J].
Intrator, J ;
Hare, R ;
Stritzke, P ;
Brichtswein, K ;
Dorfman, D ;
Harpur, T ;
Bernstein, D ;
Handelsman, L ;
Schaefer, C ;
Keilp, J ;
Rosen, J ;
Machac, J .
BIOLOGICAL PSYCHIATRY, 1997, 42 (02) :96-103
[36]   Temporal lobe abnormalities in semantic processing by criminal psychopaths as revealed by functional magnetic resonance imaging [J].
Kiehl, KA ;
Smith, AM ;
Mendrek, A ;
Forster, BB ;
Hare, RD ;
Liddle, PF .
PSYCHIATRY RESEARCH-NEUROIMAGING, 2004, 130 (01) :27-42
[37]   Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging [J].
Kiehl, KA ;
Smith, AM ;
Hare, RD ;
Mendrek, A ;
Forster, BB ;
Brink, J ;
Liddle, PF .
BIOLOGICAL PSYCHIATRY, 2001, 50 (09) :677-684
[38]   A cognitive neuroscience perspective on psychopathy: Evidence for paralimbic system dysfunction [J].
Kiehl, Kent A. .
PSYCHIATRY RESEARCH, 2006, 142 (2-3) :107-128
[39]   Lateralized and frequency-dependent effects of prefrontal rTMS on regional cerebral blood flow [J].
Knoch, D. ;
Treyer, V. ;
Regard, M. ;
Muri, R. M. ;
Buck, A. ;
Weber, B. .
NEUROIMAGE, 2006, 31 (02) :641-648
[40]   ASSESSMENT OF AGGRESSIVE BEHAVIOR AND PLASMA TESTOSTERONE IN A YOUNG CRIMINAL POPULATION [J].
KREUZ, LE ;
ROSE, RM .
PSYCHOSOMATIC MEDICINE, 1972, 34 (04) :321-332