A highly DNA-duplex-stabilizing metal-salen base pair

被引：122

作者：

Clever, GH ^{[1
]}

Polborn, K ^{[1
]}

Carell, T ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 44期

关键词：

DNA; DNA structures; metal-base pairs; nucleobases;

D O I：

10.1002/anie.200501589

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Stabilizing influence: When a DNA duplex containing two salicylic aldehyde nucleosides facing each other is treated with ethylenediamine and one equivalent of a Cu2+ or Mn2+ salt, a metal-salen base pair is formed within the DNA. The resulting stabilization of the DNA structure is attributed to the cross-linking of the salicylic aldehyde units with ethylenediamine. (Chemical Equation Presented) © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7204 / 7208

页数：5

共 36 条

[1] Synthesis and characterization of novel ligands 1,2-bis(salicylideneaminooxy)ethanes [J].

Akine, S ;

Taniguchi, T ;

Nabeshima, T .

CHEMISTRY LETTERS, 2001, (07) :682-683

[2] SYNTHESIS OF C-GLUCOSIDES BY REACTIONS OF GLUCOSYL HALIDES WITH ORGANOCUPRATES [J].

BIHOVSKY, R ;

SELICK, C ;

GIUSTI, I .

JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (17) :4026-4031

[3] Transition metal Ligands as novel DNA-base substitutes [J].

Brotschi, C ;

Leumann, CJ .

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2003, 22 (5-8) :1195-1197

[4] Nucleic acid template-directed assembly of metallosalen-DNA conjugates [J].

Czlapinski, JL ;

Sheppard, TL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (35) :8618-8619

[5] Tetrabutylammonium tribromide (TBATB) as an efficient generator of HBr for an efficient chemoselective reagent for acetalization of carbonyl compounds [J].

Gopinath, R ;

Haque, SJ ;

Patel, BK .

JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (16) :5842-5845

[6] Modular DNA-programmed assembly of linear and branched conjugated nanostructures [J].

Gothelf, KV ;

Thomsen, A ;

Nielsen, M ;

Cló, E ;

Brown, RS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (04) :1044-1046

[7] ALPHA-THYMIDIN [J].

HOFFER, M .

CHEMISCHE BERICHTE-RECUEIL, 1960, 93 (12) :2777-2781

[8] Convenient method for the ortho-formylation of phenols [J].

Hofslokken, NU ;

Skattebol, L .

ACTA CHEMICA SCANDINAVICA, 1999, 53 (04) :258-262

[9] Unique asymmetric catalysis of cis-β metal complexes of salen and its related Schiff-base ligands [J].

Katsuki, T .

CHEMICAL SOCIETY REVIEWS, 2004, 33 (07) :437-444

[10] CATALYTIC ASYMMETRIC OXIDATIONS USING OPTICALLY-ACTIVE (SALEN)MANGANESE(III) COMPLEXES AS CATALYSTS [J].

KATSUKI, T .

COORDINATION CHEMISTRY REVIEWS, 1995, 140 :189-214

← 1 2 3 4 →