A highly DNA-duplex-stabilizing metal-salen base pair

被引：122

作者：

Clever, GH ^{[1
]}

Polborn, K ^{[1
]}

Carell, T ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 44期

关键词：

DNA; DNA structures; metal-base pairs; nucleobases;

D O I：

10.1002/anie.200501589

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Stabilizing influence: When a DNA duplex containing two salicylic aldehyde nucleosides facing each other is treated with ethylenediamine and one equivalent of a Cu2+ or Mn2+ salt, a metal-salen base pair is formed within the DNA. The resulting stabilization of the DNA structure is attributed to the cross-linking of the salicylic aldehyde units with ethylenediamine. (Chemical Equation Presented) © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7204 / 7208

页数：5

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