Photoredox-Initiated α-Alkylation of Imines through a Three-Component Radical/Cationic Reaction

被引：113

作者：

Courant, Thibaut ^{[1
]}

Masson, Geraldine ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, Ctr Rech Gif, F-91198 Gif Sur Yvette, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 02期

关键词：

alkylation; domino reactions; enamides; photoredox catalysis; radicals; VISIBLE-LIGHT PHOTOCATALYSIS; RADICAL CYCLIZATION REACTIONS; ORGANO-SOMO CATALYSIS; C-C; ENANTIOSELECTIVE SYNTHESIS; COORDINATION-COMPOUNDS; ASYMMETRIC ALKYLATION; REDUCTIVE ALKYLATION; ADDITION-REACTIONS; ALDEHYDES;

D O I：

10.1002/chem.201103062

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Radical-polar crossover reaction: The photoredox-mediated alkylation of enamides with diethyl bromomalonate in the presence of alcohols has been developed. This multicomponent domino process affords β-alkylated α-carbamido ethers as stables imine surrogates in good to excellent yields under mild conditions (see scheme). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：423 / 427

页数：5

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