In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT)

被引:216
作者
Enfield, Joey [1 ]
Jonathan, Enock [1 ]
Leahy, Martin [1 ,2 ]
机构
[1] Natl Biophoton & Imaging Platform, Tissue Opt & Microcirculat Imaging Facil, Limerick, Ireland
[2] Royal Coll Surg RCSI, Dublin, Ireland
来源
BIOMEDICAL OPTICS EXPRESS | 2011年 / 2卷 / 05期
关键词
VASCULAR PERFUSION; FLOW VELOCITY; BLOOD-FLOW; SKIN; CAPILLAROSCOPY;
D O I
10.1364/BOE.2.001184
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Correlation mapping optical coherence tomography (cmOCT) is a recently proposed technique that extends the capabilities of OCT to enable mapping of vasculature networks. The technique is achieved as a processing step on OCT intensity images that does not require any modification to existing OCT hardware. In this paper we apply the cmOCT processing technique to in vivo human imaging of the volar forearm. We illustrate that cmOCT can produce maps of the microcirculation that clearly follow the accepted anatomical structure. We demonstrate that the technique can extract parameters such as capillary density and vessel diameter. These parameters are key clinical markers for the early changes associated with microvascular diseases. Overall the presented results show that cmOCT is a powerful new tool that generates microcirculation maps in a safe non-invasive, non-contact technique which has clear clinical applications. (C) 2011 Optical Society of America
引用
收藏
页码:1184 / 1193
页数:10
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