Potential of poly(amidoamine) dendrimers as drug carriers of camptothecin based on encapsulation studies

被引：56

作者：

Cheng, Yiyun ^{[1
,2
,3
]}

Li, Minghong ^{[1
]}

Xu, Tongwen ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

[2] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China

[3] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 08期

关键词：

poly(amidoamine) dendrimers; PAMAM; drug carrier; anti-cancer drugs; camptothecin; solubility;

D O I：

10.1016/j.ejmech.2007.09.030

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Camptothecin (CPT), a plant alkaloid isolated from Camptotheca acuminata, has an extremely low solubility in aqueous medium, which presents a major challenge during drug formulation in clinical trails. In the present study we investigated the potential of poly(amidoamine) (PAMAM) dendrimers as drug carriers of CPT through aqueous solubility studies. Results showed that the aqueous solubility of CPT was significantly increased by PAMAM dendrimers. The effect of PAMAM generation on CPT solubility was also evaluated. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of CPT. (C) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：1791 / 1795

页数：5

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