Histone Modifications and Cancer

被引：764

作者：

Audia, James E. ^{[1
]}

Campbell, Robert M. ^{[2
]}

机构：

[1] Constellat Pharmaceut, Cambridge, MA 02142 USA

[2] Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2016年 / 8卷 / 04期

基金：

美国国家卫生研究院;

关键词：

CELL-CYCLE PROGRESSION; ARGININE METHYLTRANSFERASE 5; ESTROGEN-RECEPTOR-ALPHA; GROUP PROTEINS RING1A/B; TUMOR-SUPPRESSOR; COLORECTAL-CANCER; SWI/SNF COMPLEXES; CLASS-I; LYSINE METHYLTRANSFERASE; CHROMATIN MODIFICATIONS;

D O I：

10.1101/cshperspect.a019521

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Histone posttranslational modifications represent a versatile set of epigenetic marks involved not only in dynamic cellular processes, such as transcription and DNA repair, but also in the stable maintenance of repressive chromatin. In this article, we review many of the key and newly identified histone modifications known to be deregulated in cancer and how this impacts function. The latter part of the article addresses the challenges and current status of the epigenetic drug development process as it applies to cancer therapeutics.

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页数：31

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