Genetic heterologous prime-boost vaccination strategies for improved systemic and mucosal immunity

被引：37

作者：

Ranasinghe, Charani ^{[1
]}

Ramshaw, Ian A. ^{[1
]}

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Emerging Pathogens & vaccines Program, Canberra, ACT 2601, Australia

来源：

EXPERT REVIEW OF VACCINES | 2009年 / 8卷 / 09期

基金：

英国医学研究理事会;

关键词：

cell-mediated immunity; costimulatory molecule; DNA vaccine; HIV; mucosal vaccine; prime-boost; T-cell avidity; CD8(+) T-CELLS; RECOMBINANT FOWLPOX VIRUS; DRAINING LYMPH-NODES; PHASE-I TRIAL; VACCINIA VIRUS; DNA VACCINES; ANTIBODY-RESPONSES; NONHUMAN-PRIMATES; VIRAL REPLICATION; RHESUS MACAQUES;

D O I：

10.1586/ERV.09.86

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this article, we discuss the advantages and progress made with heterologous prime-boost vaccination strategies. Although the consecutive use of DNA and recombinant viral vectors induce greatly enhanced and sustained levels of both cell-mediated and humoral immunity in preclinical models, the results have not yet been translated to clinical use. Despite this, there is still a high level of optimism that these strategies offer the best hope for the development of vaccines against diseases for which there are no effective vaccines currently available. In this article, we discuss how prime-boost immunization can elicit improved mucosal immunity, how 'mucosal' regimes also elicit 'high-quality' (high-avidity) T-cell responses to vaccine antigens, and the use of cytokines/chemokines as genetic adjuvants.

引用

页码：1171 / 1181

页数：11

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