[1] Univ Cambridge, Addenbrookes Hosp, Cambridge Inst Med Res, Cambridge CB2 0XY, England
[2] Univ Cambridge, Addenbrookes Hosp, Dept Med Genet, Cambridge CB2 0XY, England
[3] Univ Liverpool, Sch Biomed Sci, Physiol Lab, Liverpool L69 3BX, Merseyside, England
[4] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 0XY, England