Solid-phase total synthesis of the pentacyclic system lamellarins U and L

被引：80

作者：

Cironi, P

Manzanares, I

Albericio, F

Alvarez, M

机构：

[1] Univ Barcelona, Inst Biomed Res, Dept Organ Chem, E-08028 Barcelona, Spain

[2] Univ Barcelona, Fac Pharm, Organ Chem Lab, Barcelona, Spain

[3] Pharma Mar, Colmenar Viejo 28770, Spain

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 16期

关键词：

D O I：

10.1021/ol0351192

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A total solid-phase synthesis of lamellarins U and L has been achieved. The conversion of an aldehyde group into a formate by a Baeyer-Villiger reaction and a intramolecular [3 + 2] cycloaddition of a 3,4-dihydroisoquinolinium salt over a triple bond comprise the key steps of the process. Each transformation has been controlled with the proper spectroscopic and analytical methods.

引用

页码：2959 / 2962

页数：4

共 42 条

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