Acute interactions between endothelin and nitric oxide in the control of renal haemodynamics

被引：16

作者：

Baylis, C ^{[1
]}

机构：

[1] W Virginia Univ, Dept Physiol, Morgantown, WV 26506 USA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1999年 / 26卷 / 03期

关键词：

afferent resistance; efferent resistance; glomerular blood pressure; glomerular filtration rate; K-f; renal plasma flow; renal vascular resistance;

D O I：

10.1046/j.1440-1681.1999.03026.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Endogenous endothelin (ET) does contribute to control of renal vascular tone via nitric oxide (NO)-dependent vasodilation in the rat, 2. Endothelin mediates some of the renal vascular responses to acute nitric oxide synthase (NOS) inhibition, being particularly important when a rise in renal perfusion pressure occurs, 3. Tonically produced NO blunts the renal vasoconstrictor responses to acutely administered ET. 4. The similarity between the renal vascular responses to ET administration and NOS inhibition is not fortuitous but, in part, reflects important interactions between these vasoactive agents.

引用

页码：253 / 257

页数：5

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