An Improved Copper-Mediated Oxidative Trifluoromethylation of Terminal Alkynes

被引：37

作者：

Zhang, Ke ^{[1
]}

Qiu, Xiao-Long ^{[2
]}

Huang, Yangen ^{[1
]}

Qing, Feng-Ling ^{[1
,3
]}

机构：

[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

[2] Wisdom Pharmaceut Co Ltd, Haimen 226100, Jiangsu, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Fluorine; Alkynes; Copper; CATALYZED TRIFLUOROMETHYLATION; NUCLEOPHILIC TRIFLUOROMETHYLATION; FLUORINE; ARYL; PERFLUOROALKYLATION; ALDEHYDES; REAGENT; ZINC;

D O I：

10.1002/ejoc.201101550

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved method for the efficient copper-mediated trifluoromethylation of terminal alkynes has been developed. This protocol highlights the convenient access to a variety of aryl-substituted trifluoromethylated alkynes by oxidative trifluoromethylation with two equivalents of TMSCF3 at room temperature.

引用

页码：58 / 61

页数：4

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