Regulatory T cell-mediated transplantation tolerance

被引：24

作者：

Bharat, Ankit ^{[1
]}

Fields, Ryan Courtney ^{[1
]}

Mohanakumar, T. ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA

来源：

IMMUNOLOGIC RESEARCH | 2005年 / 33卷 / 03期

关键词：

regulatory cells; lung transplantation; transplantation tolerance; adaptive immune response; infectious tolerance; T cells; antigen presentation;

D O I：

10.1385/IR:33:3:195

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The existence of naturally occurring regulatory T cells in normal hosts and their pivotal role in maintaining both auto- and allo-tolerance have direct implications on the therapy of autoimmune disorders and for achieving immunosuppression-free allotransplantation. Among the various forms of regulatory T cells described, CD4(+) CD25(+) T cells have emerged as one of the most potent tolerogenic subsets. In this review, we discuss the molecular basis of development and function of these regulatory T cells and their potential role in the context of chronic lung allograft rejection.

引用

页码：195 / 212

页数：18

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