An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia

被引：428

作者：

Rasmussen, Morten ^{[3
,4
,5
]}

Guo, Xiaosen ^{[5
,6
]}

Wang, Yong ^{[1
,2
]}

Lohmueller, Kirk E. ^{[1
,2
]}

Rasmussen, Simon ^{[7
]}

Albrechtsen, Anders ^{[8
]}

Skotte, Line ^{[8
]}

Lindgreen, Stinus ^{[3
,4
,8
]}

Metspalu, Mait ^{[9
,10
]}

Jombart, Thibaut ^{[11
]}

Kivisild, Toomas ^{[12
]}

Zhai, Weiwei ^{[13
]}

Eriksson, Anders ^{[14
]}

Manica, Andrea ^{[14
]}

Orlando, Ludovic ^{[3
,4
]}

De La Vega, Francisco M. ^{[15
]}

Tridico, Silvana ^{[16
]}

Metspalu, Ene ^{[9
,10
]}

Nielsen, Kasper ^{[7
]}

Avila-Arcos, Maria C. ^{[3
,4
]}

Moreno-Mayar, J. Victor ^{[3
,4
,17
]}

Muller, Craig ^{[18
]}

Dortch, Joe ^{[19
]}

Gilbert, M. Thomas P. ^{[3
,4
,5
]}

Lund, Ole ^{[7
]}

Wesolowska, Agata ^{[7
]}

Karmin, Monika ^{[9
,10
]}

Weinert, Lucy A. ^{[11
]}

Wang, Bo ^{[6
]}

Li, Jun ^{[6
]}

Tai, Shuaishuai ^{[6
]}

Xiao, Fei ^{[6
]}

Hanihara, Tsunehiko ^{[20
]}

van Driem, George ^{[21
]}

Jha, Aashish R. ^{[22
]}

Ricaut, Francois-Xavier ^{[23
]}

de Knijff, Peter ^{[24
]}

Migliano, Andrea B. ^{[12
,25
]}

Romero, Irene Gallego ^{[22
]}

Kristiansen, Karsten ^{[5
,6
,8
]}

Lambert, David M. ^{[26
,27
]}

Brunak, Soren ^{[7
,28
]}

Forster, Peter ^{[29
,30
]}

Brinkmann, Bernd ^{[30
]}

Nehlich, Olaf ^{[31
]}

Bunce, Michael ^{[16
]}

Richards, Michael ^{[31
,32
]}

Gupta, Ramneek ^{[7
]}

Bustamante, Carlos D. ^{[15
]}

Krogh, Anders ^{[3
,4
,8
]}

机构：

[1] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA

[3] Univ Copenhagen, Nat Hist Museum Denmark, Ctr GeoGenet, DK-1350 Copenhagen, Denmark

[4] Univ Copenhagen, Dept Biol, DK-1350 Copenhagen, Denmark

[5] BGI Shenzhen, Sino Danish Genom Ctr, Shenzhen 518083, Peoples R China

[6] BGI Shenzhen, Shenzhen Key Lab Trans Biotechnol, Shenzhen 518083, Peoples R China

[7] Tech Univ Denmark, Dept Syst Biol, Ctr Biol Sequence Anal, DK-2800 Lyngby, Denmark

[8] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark

[9] Univ Tartu, Dept Evolutionary Biol, EE-510101 Tartu, Estonia

[10] Estonian Bioctr, EE-510101 Tartu, Estonia

[11] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Infect Dis Epidemiol, MRC Ctr Outbreak Anal & Modeling, London W2 1PG, England

[12] Univ Cambridge, Dept Biol Anthropol, Leverhulme Ctr Human Evolutionary Studies, Cambridge CB2 1QH, England

[13] Chinese Acad Sci, Beijing Inst Genom, Beijing 100029, Peoples R China

[14] Univ Cambridge, Dept Zool, Evolutionary Ecol Grp, Cambridge CB2 3EJ, England

[15] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

[16] Murdoch Univ, Sch Biol Sci & Biotechnol, Ancient DNA Lab, Murdoch, WA 6150, Australia

[17] Univ Nacl Autonoma Mexico, Undergrad Program Genom Sci, Cuernavaca 62210, Morelos, Mexico

[18] Goldfields Land & Sea Council Aboriginal Corp, Kalgoorlie, WA 6430, Australia

[19] Univ Western Australia, Crawley, WA 6009, Australia

[20] Kitasato Univ, Sch Med, Dept Anat, Minami Ku, Sagamihara, Kanagawa 2520374, Japan

[21] Univ Bern, Sprachwissensch Inst, CH-3000 Bern 9, Switzerland

[22] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

[23] Univ Toulouse 3, CNRS, UMR 5288, Lab Anthropol Mol & Imagerie Synth, F-31073 Toulouse 3, France

[24] Leiden Univ, Med Ctr, Dept Human & Clin Genet, NL-2333 ZA Leiden, Netherlands

[25] UCL, Dept Anthropol, London WC1E 6BT, England

[26] Griffith Univ, Sch Biomol & Phys Sci, Nathan, Qld 4111, Australia

[27] Griffith Univ, Griffith Sch Environm, Nathan, Qld 4111, Australia

[28] Univ Copenhagen, Fac Hlth Sci, Novo Nordisk Fdn Ctr Prot Res, DK-2200 Copenhagen, Denmark

[29] Univ Cambridge, Murray Edwards Coll, Cambridge CB3 0DF, England

[30] Inst Forens Genet, D-48161 Munster, Germany

[31] Max Planck Inst Evolutionary Anthropol, Dept Human Evoluat, D-04103 Leipzig, Germany

[32] Univ British Columbia, Dept Anthropol, Vancouver, BC V6T 1Z1, Canada

[33] Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, DK-2800 Lyngby, Denmark

[34] Estonian Acad Sci, EE-10130 Tallinn, Estonia

[35] Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark

来源：

SCIENCE | 2011年 / 334卷 / 6052期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Y-CHROMOSOME; NEW-GUINEA; SEQUENCE; SETTLEMENT; HISTORY; MODEL;

D O I：

10.1126/science.1211177

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock of hair donated by an Aboriginal man from southern Western Australia in the early 20th century. We detect no evidence of European admixture and estimate contamination levels to be below 0.5%. We show that Aboriginal Australians are descendants of an early human dispersal into eastern Asia, possibly 62,000 to 75,000 years ago. This dispersal is separate from the one that gave rise to modern Asians 25,000 to 38,000 years ago. We also find evidence of gene flow between populations of the two dispersal waves prior to the divergence of Native Americans from modern Asian ancestors. Our findings support the hypothesis that present-day Aboriginal Australians descend from the earliest humans to occupy Australia, likely representing one of the oldest continuous populations outside Africa.

引用

页码：94 / 98

页数：5

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