Nanoparticles of carbon allotropes inhibit glioblastoma multiforme angiogenesis in ovo

被引：58

作者：

Grodzik, Marta ^{[2
]}

Sawosz, Ewa ^{[2
]}

Wierzbicki, Mateusz ^{[2
]}

Orlowski, Piotr ^{[2
]}

Hotowy, Anna ^{[1
]}

Niemiec, Tomasz ^{[2
]}

Szmidt, Maciej ^{[3
]}

Mitura, Katarzyna ^{[4
]}

Chwalibog, Andre ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Basic Anim & Vet Sci, DK-1870 Frederiksberg, Denmark

[2] Warsaw Univ Life Sci, Div Biotechnol & Biochem Nutr, Warsaw, Poland

[3] Warsaw Univ Life Sci, Div Histol & Embryol, Warsaw, Poland

[4] Koszalin Univ Technol, Dept Biomed Engn, Koszalin, Poland

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2011年 / 6卷

关键词：

cancer; nanoparticle; embryo; angiogenesis; FGF-2; VEGF; ENDOTHELIAL GROWTH-FACTOR; RENAL-CELL CARCINOMA; IN-VIVO; TUMOR VASCULARIZATION; DOWN-REGULATION; BRAIN-TUMORS; CANCER; VEGF; ANTIANGIOGENESIS; PROLIFERATION;

D O I：

10.2147/IJN.S25528

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

The objective of the study was to determine the effect of carbon nanoparticles produced by different methods on the growth of brain tumor and the development of blood vessels. Glioblastoma multiforme cells were cultured on the chorioallantoic membrane of chicken embryo and after 7 days of incubation, were treated with carbon nanoparticles administered in ovo to the tumor. Both types of nanoparticles significantly decreased tumor mass and volume, and vessel area. Quantitative real-time polymerase chain reaction analysis showed downregulated fibroblast growth factor-2 and vascular endothelial growth factor expression at the messenger ribonucleic acid level. The present results demonstrate antiangiogenic activity of carbon nanoparticles, making them potential factors for anticancer therapy.

引用

页码：3041 / 3048

页数：8

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