Solution phase combinatorial synthesis of biaryl libraries employing heterogeneous conditions for catalysis and isolation with size exclusion chromatography for purification

A convenient and effective approach to the solution phase synthesis of biaryl libraries from iodoarenes is described enlisting 10% Pd-C as an inexpensive and readily available supported catalyst. Isolation and purification of small library mixtures, individual library members, and intermediates in the multistep sequence by a combination of liquid-liquid and liquid-solid extractions and size exclusion chromatography are detailed.