Selective transport of water mediated by porous dendritic dipeptides

被引：146

作者：

Kaucher, Mark S.

Peterca, Mihai

Dulcey, Andres E.

Kim, Anthony J.

Vinogradov, Sergei A.

Hammer, Danniel A.

Heiney, Paul A.

Percec, Virgil ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Lab, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Engn & Appl Sci, Inst Med & Engn, Dept Bioengn, Philadelphia, PA 19104 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 38期

关键词：

D O I：

10.1021/ja076066c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The replacement of the benzyl ethers from the periphery of self-assembling dendritic dipeptides with naphthyl ethers provided the simplest mechanism to enhance the thermal stability of their supramolecular pores in bulk, solution, and in vesicles. This strategy facilitated transport studies via dendritic dipeptide pores reconstituted in phospholipid vesicles and demonstrated that hydrophobic pores with D (pore) 14.5 +/- 1.5 angstrom transport water and protons and do not transport Li+, Na+, and Cl-. Therefore, these pores provide a primitive mimic of Aquaporin that selectively transports water but does not reject protons.

引用

页码：11698 / +

页数：3

共 17 条

[1] Aquaporin water channels (Nobel lecture) [J].