Inbred strain variation in contextual and cued fear conditioning behavior

A number of commonly used inbred strains were surveyed in a fear-conditioning paradigm conducted with an automated computer-controlled system. Control studies were used to verify the automated system. Response to shock was also monitored to determine if it was associated with contextual and/or cued conditioning behavior. After three pairings of tone with shock, fear conditioning was measured 24 h later in 129S1/SvImJ (129), A/J (A), BALB/cByJ (BALB), C3H/HeJ (C3H), C57BL/6J (B6), CBA/J (CBA), DBA/2J (D2), and FVB/NJ (FVB) male and female mice. There were both significant strain acid sex differences in response. To determine the effects of vision on this behavior, C3H mice (with retinal degeneration) were compared with C3.BLiA-+(Pdc6b) congenics (withoul retinal degeneration). Here, vision was Found to pl:ly a minimal role in responsiveness in this paradigm. Because this fear-conditioning test is;automated, it can be used for the rapid screening of ii large number of mice, such as required fur mutagenesis studies.