Inhibition of cholesterol absorption by plant sterols for mass intervention

被引：80

作者：

Ikeda, I

Sugano, M

机构：

[1] Prefectural Univ Kumamoto, Fac Human Life Sci, Kumamoto 8628502, Japan

[2] Kyushu Univ, Fac Agr, Nutr Chem Lab, Fukuoka 812, Japan

来源：

CURRENT OPINION IN LIPIDOLOGY | 1998年 / 9卷 / 06期

关键词：

D O I：

10.1097/00041433-199812000-00003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plant sterols and stanols lower serum cholesterol by inhibiting intestinal absorption of cholesterol. Because of their safety and efficacy, their application for mass intervention is promising. The use of fatty acid esters of stanols is particularly helpful because stanols readily mix with dietary fats in this form and their hypocholesterolemic efficacy is greater than in the free form. Curr Opin Lipidol 9:527-531. (C) 1998 Lippincott Williams & Wilkins.

引用

收藏

页码：527 / 531

页数：5

相关论文

共 41 条

[21] Dietary phytosterols as cholesterol-lowering agents in humans [J].

Jones, PJH ;

MacDougall, DE ;

Ntanios, F ;

Vanstone, CA .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1997, 75 (03) :217-227

[22] Short-term administration of tall oil phytosterols improves plasma lipid profiles in subjects with different cholesterol levels [J].

Jones, PJH ;

Howell, T ;

MacDougall, DE ;

Feng, JY ;

Parsons, W .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1998, 47 (06) :751-756

[23] BY HOW MUCH AND HOW QUICKLY DOES REDUCTION IN SERUM-CHOLESTEROL CONCENTRATION LOWER RISK OF ISCHEMIC-HEART-DISEASE [J].

LAW, MR ;

WALD, NJ ;

THOMPSON, SG .

BMJ-BRITISH MEDICAL JOURNAL, 1994, 308 (6925) :367-373

[24] PLANT STEROLS AS CHOLESTEROL-LOWERING AGENTS - CLINICAL-TRIALS IN PATIENTS WITH HYPERCHOLESTEROLEMIA AND STUDIES OF STEROL BALANCE [J].

LEES, AM ;

MOK, HYI ;

LEES, RS ;

MCCLUSKEY, MA ;

GRUNDY, SM .

ATHEROSCLEROSIS, 1977, 28 (03) :325-338

[25] DIETARY PHYTOSTEROLS - A REVIEW OF METABOLISM, BENEFITS AND SIDE-EFFECTS [J].

LING, WH ;

JONES, PJH .

LIFE SCIENCES, 1995, 57 (03) :195-206

[26] DIETARY SITOSTANOL RELATED TO ABSORPTION, SYNTHESIS AND SERUM LEVEL OF CHOLESTEROL IN DIFFERENT APOLIPOPROTEIN-E PHENOTYPES [J].

MIETTINEN, TA ;

VANHANEN, H .

ATHEROSCLEROSIS, 1994, 105 (02) :217-226

[27] CHOLESTEROL ABSORPTION - REGULATION OF CHOLESTEROL-SYNTHESIS AND ELIMINATION AND WITHIN-POPULATION VARIATIONS OF SERUM-CHOLESTEROL LEVELS [J].

MIETTINEN, TA ;

KESANIEMI, YA .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1989, 49 (04) :629-635

[28] SERUM PLANT STEROLS AND CHOLESTEROL PRECURSORS REFLECT CHOLESTEROL ABSORPTION AND SYNTHESIS IN VOLUNTEERS OF A RANDOMLY SELECTED MALE-POPULATION [J].

MIETTINEN, TA ;

TILVIS, RS ;

KESANIEMI, YA .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1990, 131 (01) :20-31

[29] REDUCTION OF SERUM-CHOLESTEROL WITH SITOSTANOL-ESTER MARGARINE IN A MILDLY HYPERCHOLESTEROLEMIC POPULATION [J].

MIETTINEN, TA ;

PUSKA, P ;

GYLLING, H ;

VANHANEN, H ;

VARTIAINEN, E .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (20) :1308-1312

[30] ''Tall oil''-derived phytosterols reduce atherosclerosis in ApoE-deficient mice [J].

Moghadasian, MH ;

McManus, BM ;

Pritchard, PH ;

Frohlich, JJ .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (01) :119-126

← 1 2 3 4 5 →