The Emerging Role of Interleukin-1β in Autoinflammatory Diseases

被引：24

作者：

Lane, Thirusha ^{[1
]}

Lachmann, Helen J. ^{[1
]}

机构：

[1] UCL Med Sch, Natl Amyloidosis Ctr, Div Med, London NW3 2PF, England

来源：

CURRENT ALLERGY AND ASTHMA REPORTS | 2011年 / 11卷 / 05期

关键词：

Interleukin-1; Inflammasome; Autoinflammatory diseases; Caspase-1; Cryopyrin; NLRP3; CAPS; Anakinra; Rilonacept; Canakinumab; JUVENILE IDIOPATHIC ARTHRITIS; FAMILIAL MEDITERRANEAN FEVER; RECEPTOR ANTAGONIST ANAKINRA; HYPERIMMUNOGLOBULINEMIA-D SYNDROME; PERIODIC SYNDROME; FOLLOW-UP; RHEUMATOID-ARTHRITIS; PYOGENIC ARTHRITIS; ARTICULAR SYNDROME; MOLECULAR ANALYSIS;

D O I：

10.1007/s11882-011-0207-6

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The autoinflammatory syndromes are a group of multisystem disorders characterized by recurrent episodes of fever and systemic inflammation affecting the eyes, joints, skin, and serosal surfaces in the absence of an immune reaction. Recent advances have revealed the importance of interleukin-1 beta, not only in the pathogenesis of many of these rare inherited diseases, but also in acquired diseases. The development and availability of anti-interleukin-1 beta therapeutics have introduced the possibility of proof-of-concept studies, which are likely to further widen this field.

引用

页码：361 / 368

页数：8

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