The role of STAT3 in liver regeneration

被引：24

作者：

Terui, K

Ozaki, M

机构：

[1] Hokkaido Univ, Grad Sch Med, Fac Med,Dept Surg, Div Organ Transplantat & Regenerat Med,Kita Ku, Sapporo, Hokkaido 0608638, Japan

[2] Chiba Univ, Grad Sch Med, Dept Pediat Surg, Chiba, Japan

[3] Natl Res Inst Child Hlth, Dept Innovat Surg, Bioengn Lab, Tokyo, Japan

来源：

DRUGS OF TODAY | 2005年 / 41卷 / 07期

关键词：

D O I：

10.1358/dot.2005.41.7.893622

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Liver regeneration is a process in which the liver recovers its mass and function after injury due to various causes such as hepatectomy, virus infection and intoxication. This regeneration invokes a series of complex processes which may involve the actions of various cytokines, cell proliferation and cell growth. In response to cytokine stimuli, receptor-mediated signaling systems are activated, and many proteins are transcriptionally up-regulated to increase liver mass and improve liver function. In this review, we focus on the roles of signal transducer and activator of transcription-3 (STAT3) and its functions in mitogenic and other responses during liver regeneration following hepatectomy. We also describe newly discovered target genes of STAT3 and discuss their potential roles in liver regeneration after injury due to various causes. (C) 2005 Prous Science. All rights reserved.

引用

页码：461 / 469

页数：9

共 109 条

[21] Activation of interleukin-6/STAT3 and liver regeneration following transplantation [J].