SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK)

被引：46

作者：

Lawler, S ^{[1
]}

Cuenda, A ^{[1
]}

Goedert, M ^{[1
]}

Cohen, P ^{[1
]}

机构：

[1] MRC,MOL BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

FEBS LETTERS | 1997年 / 414卷 / 01期

基金：

英国医学研究理事会;

关键词：

SAPK; JNK; p38; MAP kinase; cytokine; stress;

D O I：

10.1016/S0014-5793(97)00990-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA was cloned and expressed that encodes human stress-activated protein kinase kinase-4 (SKK4), a novel MAP kinase kinase family member whose mRNA is widely expressed in human tissues. SKK4 activated SAPK1/JNK in vitro, but not SAPK2a/p38, SAPK2b/p38 beta, SAPK3/ERK6 or SAPK4, It appears to be the mammalian homologue of HEP, an activator of SAPK1/JNK in Drosophila. In human epithelial KB cells SKK4 and SKK1/MKK4 (another activator of SAPK1/JNK) were both activated by stressful stimuli, but only SKK4 was activated by proinflammatory cytokines, The identification of SKK4 explains why the major SAPK1/JNK activator detected in many mammalian cell extracts is chromatographically separable from SKK1/MKK4. (C) 1997 Federation of European Biochemical Societies.

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页码：153 / 158

页数：6

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