Testis-specific histone H3 expression in somatic cells

被引：30

作者：

Govin, J ^{[1
]}

Caron, C ^{[1
]}

Rousseaux, S ^{[1
]}

Khochbin, S ^{[1
]}

机构：

[1] Fac Med, Inst Albert Bonniot, INSERM, U309,Lab Biol Mol & Cellulaire,Differenciat Equip, F-38706 La Tronche, France

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 07期

关键词：

D O I：

10.1016/j.tibs.2005.05.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone variants functionally differentiate individual nucleosomes and, hence, act as key regulators of chromatin structure and function. Large-scale proteomic projects are now valuable sources of histone-variant discovery, showing, in particular, that somatic mammalian cells express a larger panel of histone H3 variants than previously thought, including testis-specific variants and as yet uncharacterized species. These data also suggest a tight relationship between the complexity of histone-variant expression and physiopathological states of the cells.

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收藏

页码：357 / 359

页数：3

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