SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation - II. Structure elucidation

被引：16

作者：

Kawamura, Tatsuro ^{[1
]}

Tashiro, Etsu ^{[1
]}

Shindo, Kazutoshi ^{[2
]}

Imoto, Masaya ^{[1
]}

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Biosci & Informat, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

[2] Japan Womens Univ, Dept Food & Nutr, Bunkyo Ku, Tokyo 1128681, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 05期

关键词：

triene-ansamycin; ER stress; XBP1;

D O I：

10.1038/ja.2008.44

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

Four novel triene-ansamycin group compounds, quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol, were isolated from the culture broth of Streptomyces sp. PAE37 as inhibitors of ER stress-induced XBP1 activation. The structures of quinotrierixin, demethyltrienomycin A, demethyltrienomycin B and demethyltrienomycinol were determined on the basis of their spectroscopical and chemical properties. All of four possessed 21-membered macrocyclic lactams including triene moieties.

引用

收藏

页码：312 / 317

页数：6

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