Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor

被引：127

作者：

Browne, Duncan L. ^{[1
]}

Deadman, Benjamin J. ^{[1
]}

Ashe, Robert ^{[2
]}

Baxendale, Ian R. ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

[2] AM Technol, Runcorn WA7 4QX, Cheshire, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2011年 / 15卷 / 03期

关键词：

ORGANIC-SYNTHESIS; MICROREACTOR; SCAVENGERS; CHEMISTRY; CYCLOADDITION; REAGENTS; SEQUENCE; AZIDES;

D O I：

10.1021/op2000223

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A general method for the continuous processing of suspensions and particulates is reported. A commercially available agitating cell reactor which uses a transverse mixing motion to maintain solids in suspension has been successfully applied to a salt-forming reaction. The flow device delivered 208 g of N-iodomorpholinium hydroiodide salt over a 9-h period (equating to 3.88 kg/week) under optimized conditions. The reactor is suitable for the medium-scale (5 kg) processing of solid-forming reactions and appears to offer the potential for a variety of more complex applications.

引用

页码：693 / 697

页数：5

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