TrkB as a therapeutic target for ovarian cancer

被引：28

作者：

Siu, Michelle K. Y. ^{[1
]}

Wong, Oscar G. W. ^{[1
]}

Cheung, Annie N. Y. ^{[1
]}

机构：

[1] Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2009年 / 13卷 / 10期

关键词：

BDNF; ovarian cancer; therapeutic target; TrkB; NEUROTROPHIC FACTOR ACTIVATION; FOLLICLE-STIMULATING-HORMONE; TYROSINE KINASE INHIBITOR; HEPATOCYTE GROWTH-FACTOR; PROTECTS NEUROBLASTOMA-CELLS; PHASE-I TRIAL; RECEPTOR TRKB; SIGNAL-TRANSDUCTION; CEP-751; KT-6587; AUTOPHOSPHORYLATION SITES;

D O I：

10.1517/14728220903196787

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: In many countries, ovarian cancer is the most lethal gynecological malignancy. Its poor prognosis is mainly due to the late stage of disease with metastasis at presentation. The significant failure rate of chemotherapy in patients with advanced stage disease is also a main concern. As such, developing novel therapeutic targets is essential to improve long-term survival. Overexpression of Tropomyosin-related kinase B (TrkB), a tyrosine kinase receptor, has been documented in ovarian cancer and is found to be correlated with poor prognosis. Objective/methods: We discuss the functional roles and the related downstream signaling pathways of TrkB and its ligand brain-derived neurotrophic factor (BDNF) in ovarian cancer. The possible crosstalk between TrkB/BDNF and other putative molecular targets in ovarian cancer is also discussed. Results/conclusions: All these latest findings shed light on the application of TrkB as a therapeutic target for ovarian cancer.

引用

页码：1169 / 1178

页数：10

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