Increased detection of 14-3-3 protein in cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease during the disease course

被引：20

作者：

Giraud, P

Biacabe, AG

Chazot, G

Later, R

Joyeux, O

Moene, Y

Perret-Liaudet, A

机构：

[1] Ctr Hosp Gen Annecy, Serv Neurol A, F-74000 Annecy, France

[2] Hop Neurol, Federat Maladies Prions, Serv Neurol D & Biochim, Lyon, France

[3] Ctr Hosp Gen Valence, Lyon, France

[4] Agence Francaise Securite Sanitaire Aliments, Lyon, France

来源：

EUROPEAN NEUROLOGY | 2002年 / 48卷 / 04期

关键词：

Creutzfeldt-Jakob; protein; 14-3-3; EEG; CSF protein;

D O I：

10.1159/000066174

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Diagnosis of Creutzfeldt-Jakob Disease (CJD) is based on neurological signs associated with characteristic electroencephalographic activity or detection of 14-3-3 protein in cerebrospinal fluid. However, the time course of 14-3-3 protein release during sporadic CJD is unknown. We report two observations in which the level of the detected 14-3-3 protein increased significantly with time. These preliminary cases suggest that there may be an increased release of 14-3-3 protein during the course of CJD as already proven for iatrogenic CJD. Copyright (C) 2002 S. Karger AG, Basel.

引用

页码：218 / 221

页数：4

共 13 条

[1] 14-3-3 protein, neuron-specific enolase, and S-100 protein in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease [J].