Novel chitin and chitosan nanofibers in biomedical applications

被引：746

作者：

Jayakumar, R. ^{[1
,2
]}

Prabaharan, M. ^{[3
]}

Nair, S. V. ^{[1
,2
]}

Tamura, H. ^{[4
,5
]}

机构：

[1] Amrita Vishwa Vidhyapeetham Univ, Amrita Ctr Nanosci & Mol Med, Amrita Inst Med Sci, Cochin 682041, Kerala, India

[2] Amrita Vishwa Vidhyapeetham Univ, Res Ctr, Cochin 682041, Kerala, India

[3] SRM Univ, Dept Chem, Fac Engn & Technol, Kattankulathur 603203, India

[4] Kansai Univ, Fac Chem Mat & Bioengn, Osaka 5648680, Japan

[5] Kansai Univ, High Technol Res Ctr, Osaka 5648680, Japan

来源：

BIOTECHNOLOGY ADVANCES | 2010年 / 28卷 / 01期

关键词：

Chitin; Chitosan; Nanofibers; Tissue engineering; Drug delivery; Biosensors; Wound healing; Filtration; HYDROXYAPATITE COMPOSITE MEMBRANES; NORMAL HUMAN KERATINOCYTES; POLY(ETHYLENE OXIDE); INTERMOLECULAR INTERACTIONS; ANTIBACTERIAL ACTIVITY; QUATERNIZED CHITOSAN; DEGRADATION BEHAVIOR; BLOOD COMPATIBILITY; THERMAL-PROPERTIES; ACETIC-ACID;

D O I：

10.1016/j.biotechadv.2009.11.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chitin and its deacetylated derivative, chitosan, are non-toxic, antibacterial. biodegradable and biocompatible biopolymers. Due to these properties, they are widely used for biomedical applications such as tissue engineering scaffolds, drug delivery, wound dressings, separation membranes and antibacterial coatings, stent coatings, and sensors. In the recent years, electrospinning has been found to be a novel technique to produce chitin and chitosan nanofibers. These nanofibers find novel applications in biomedical fields due to their high surface area and porosity. This article reviews the recent reports on the preparation, properties and biomedical applications of chitin and chitosan based nanofibers in detail. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：142 / 150

页数：9

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