Required techniques and useful molecular markers in the neuropathologic diagnosis of neurodegenerative diseases

被引：57

作者：

Dickson, D

机构：

[1] Mayo Clin, Coll Med, Dept Pathol Neuropathol, Jacksonville, FL 32224 USA

[2] Mayo Clin, Coll Med, Dept Neurosci, Jacksonville, FL 32224 USA

来源：

ACTA NEUROPATHOLOGICA | 2005年 / 109卷 / 01期

关键词：

amyloid; dementia; immunohistochemistry; parkinsonism; tau;

D O I：

10.1007/s00401-004-0950-z

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Modern neuropathologic methods and molecular biology have lead to increased understanding of neurodegenerative disorders and biologically based classifications of these disorders. The purpose of this review is to discuss neuropathologic methods that are useful in the characterization of neurodegenerative disorders, with emphasis on disorders of late life that present with dementia or movement disorders. A diagnostic algorithm is suggested for neuropathologic evaluation of neurodegenerative disorders. The importance of clinical information is emphasized in arriving at the most precise and meaningful neuropathologic diagnosis.

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收藏

页码：14 / 24

页数：11

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