Enantioselective synthesis of non-proteinogenic 2-arylallyl-α-amino acids via Pd/In catalytic cascades

被引：37

作者：

Grigg, Ronald ^{[1
]}

McCaffrey, Shaun

Sridharan, Visuvanathar

Fishwick, Colin W. G.

Kilner, Colin

Korn, Stewart

Bailey, Kevin

Blacker, John

机构：

[1] Univ Leeds, Sch Chem, MIDAS Ctr, Leeds LS2 9JT, W Yorkshire, England

[2] Avecia Ltd, Huddersfield HD2 1GA, W Yorkshire, England

来源：

TETRAHEDRON | 2006年 / 62卷 / 52期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/j.tet.2006.09.098

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of both R- and S-enantiomers of 2-arylallyl-alpha-amino acids via a diastereoselective Pd/In mediated catalytic allylation of chiral N-sulfinyl-alpha-imino esters is described. The potential for further enhancement of molecular complexity and creating contiguous chiral centres by interfacing these processes with catalytic cyclisation-anion capture methodology is demonstrated. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：12159 / 12171

页数：13

共 16 条

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