Oncogenic tyrosine kinases and the DNA-damage response

被引：111

作者：

Skorski, T ^{[1
]}

机构：

[1] Temple Univ, Coll Sci & Technol, Ctr Biotechnol, Philadelphia, PA 19122 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc799

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oncogenic tyrosine kinases (OTKs) are involved in the induction of many types of tumour, including haematological malignancies and cancers of the breast, prostate, colon and lung. Neoplastic cells that express OTKs are usually resistant to apoptosis that is induced by DNA-damaging agents, such as cytostatic drugs and irradiation, and they display genomic instability. So, what are the mechanisms involved, and what is the potential for overcoming OTK-mediated resistance in the clinic?.

引用

页码：351 / 360

页数：10

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