Towards advanced chemical and biological nanosensors - An overview

被引：279

作者：

Yonzon, CR ^{[1
]}

Stuart, DA ^{[1
]}

Zhang, XY ^{[1
]}

McFarland, AD ^{[1
]}

Haynes, CL ^{[1
]}

Van Duyne, RP ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

来源：

TALANTA | 2005年 / 67卷 / 03期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

localized surface plasmon resonance; surface-enhanced Raman scattering; metal film over nanosphere; nanosensor; nanosphere lithography;

D O I：

10.1016/j.talanta.2005.06.039

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper reviews recent developments in the design and application of two types of optical nanosensor, those based on: (1) localized surface plasmon resonance (LSPR) spectroscopy and (2) surface-enhanced Raman scattering (SERS). The performance of these sensors is discussed in the context of biological and chemical sensing. The first section addresses the LSPR sensors. Arrays of nanotriangles were evaluated and characterized using realistic protein/ligand interactions. Isolated, single nanoparticles were used for chemosensing and performed comparably to the nanoparticle array sensors. In particular, we highlight the effect of nanoparticle morphology on sensing response. The second section details the use of SERS sensors using metal film over nanosphere (MFON) surfaces. The high SERS enhancements and long-term stability of MFONs were exploited in order to develop SERS-based sensors for two important target molecules: a Bacillus anthracis biomarker and glucose in a serum protein mixture. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：438 / 448

页数：11

共 77 条

[71] Using a synthetic receptor to create an optical-sensing ensemble for a class of analytes: A colorimetric assay for the aging of scotch [J].