Dopamine and adult neurogenesis

被引：156

作者：

Borta, Andreas ^{[1
]}

Hoeglinger, Guenter U. ^{[1
]}

机构：

[1] Univ Marburg, D-35033 Marburg, Germany

来源：

JOURNAL OF NEUROCHEMISTRY | 2007年 / 100卷 / 03期

关键词：

adult neurogenesis; dopamine; Parkinson's disease; substantia nigra; subventricular zone;

D O I：

10.1111/j.1471-4159.2006.04241.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dopamine is an important neurotransmitter implicated in the regulation of mood, motivation and movement. We have reviewed here recent data suggesting that dopamine, in addition to being a neurotransmitter, also plays a role in the regulation of endogenous neurogenesis in the adult mammalian brain. In addition, we approach a highly controversial question: can the adult human brain use neurogenesis to replace the dopaminergic neurones in the substantia nigra that are lost in Parkinson's disease?

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收藏

页码：587 / 595

页数：9

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