Sphingolipids in cardiovascular diseases and metabolic disorders

被引：148

作者：

Borodzicz, Sonia ^{[1
,2
]}

Czarzasta, Katarzyna ^{[1
]}

Kuch, Marek ^{[3
,4
,5
]}

Cudnoch-Jedrzejewska, Agnieszka ^{[1
]}

机构：

[1] Med Univ Warsaw, Fac Med 1, Lab Ctr Preclin Res, Dept Expt & Clin Physiol, PL-02097 Warsaw, Poland

[2] Med Univ Warsaw, Dept Cardiol 1, PL-02097 Warsaw, Poland

[3] Med Univ Warsaw, Fac Med 2, Dept Heart Failure, PL-03242 Warsaw, Poland

[4] Med Univ Warsaw, Fac Med 2, Cardiac Rehabil Chair, PL-03242 Warsaw, Poland

[5] Med Univ Warsaw, Fac Med 2, Dept Cardiol Hypertens & Internal Dis, PL-03242 Warsaw, Poland

来源：

LIPIDS IN HEALTH AND DISEASE | 2015年 / 14卷

关键词：

Sphingolipids; Ceramide; Sphingosine-1-phosphate; Cardiovascular diseases; Metabolic disorders; CEREBRAL-ISCHEMIA; RESPIRATORY-CHAIN; CELL-DEATH; CERAMIDE; SPHINGOSINE; SPHINGOSINE-1-PHOSPHATE; SPHINGOMYELINASE; ACTIVATION; PLASMA; INHIBITION;

D O I：

10.1186/s12944-015-0053-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Many investigations suggest the pivotal role of sphingolipids in the pathogenesis of lifestyle diseases such as myocardial infarction, hypertension, stroke, diabetes mellitus type 2 and obesity. Some studies suggest that sphingolipids are important factors in cellular signal transduction. They serve as biologically active components of cell membrane and are involved in many processes such as proliferation, maturation and apoptosis. Recently, ceramide and sphingosine-1-phosphate have become the target of many investigations. Ceramide is generated in three metabolic pathways and many factors induce its production as a cellular stress response. Ceramide has proapoptotic properties and acts as a precursor for many other sphingolipids. Sphingosine-1-phosphate is a ceramide derivative, acting antiapoptotically and mitogenically and it is importantly involved in cardioprotection. Further research on the involvement of sphingolipids in cellular pathophysiology may improve the prevention and therapy of lifestyle diseases.

引用

页数：8

共 70 条

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