The effect of synthesis medium on structure and drug delivery behavior of CTAB-assisted sol-gel derived nanoporous calcium-magnesium-silicate

被引：25

作者：

Ghadiri, Sadegh ^{[1
]}

Hassanzadeh-Tabrizi, S. A. ^{[2
]}

Bigham, Ashkan ^{[1
]}

机构：

[1] Islamic Azad Univ, Najafabad Branch, Dept Mat Engn, Adv Mat Res Ctr, Najafabad, Iran

[2] Islamic Azad Univ, Najafabad Branch, Young Researchers & Elite Club, Najafabad, Iran

来源：

JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY | 2017年 / 83卷 / 01期

关键词：

Sol-gel; Drug delivery; Mesoporous; Calcium-magnesium-silicate; Ibuprofen; MESOPOROUS SILICA; SYSTEM; NANOCOMPOSITE; BIOCERAMICS; SCAFFOLDS; AEROGELS;

D O I：

10.1007/s10971-017-4404-1

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

081705 [工业催化]; 082905 [生物质能源与材料];

摘要：

In the present study, mesoporous calcium-magnesium-silicate was prepared via cetyltrimethylammonium bromide (CTAB)-assisted sol-gel method in both acidic and alkaline mediums. The effects of synthesis medium on structural properties, and drug delivery behavior of mesoporous calcium-magnesium-silicate by using ibuprofen as model drug are investigated. The X-ray diffraction results of the samples calcined at 600 A degrees C showed that the sample synthesized at alkaline environment is composed of CaSiO3 and CaMgSiO4 phases, whereas in acidic condition the sample consists of akermanite, CaMgSiO4, CaSiO3, and MgO. The specific surface area of the mesoporous calcium-magnesium-silicate samples prepared in acidic and alkaline conditions were 220 and 140 m(2)/g, respectively. The mesoporous calcium-magnesium-silicate sample synthesized in the acidic condition resulted in smaller particles with a size ranging between 50 and 100 nm. Encapsulation of ibuprofen into mesoporous calcium-magnesium-silicate was studied as a function of time. [GRAPHICS] .

引用

页码：229 / 236

页数：8

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