BAFF and the plasticity of peripheral B cell tolerance

被引：66

作者：

Stadanlick, Jason E. ^{[1
]}

Cancro, Michael P. ^{[1
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2008年 / 20卷 / 02期

关键词：

D O I：

10.1016/j.coi.2008.03.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BAFF and its receptors play a crucial role in peripheral B cell selection and survival, by dictating the set point for mature primary B cell numbers and adjusting thresholds for specificity-based selection during transitional differentiation. The notion that selective stringency can be varied on the basis of homeostatic demands reveals a previously unappreciated degree of plasticity in B cell tolerance, and suggests a paradigm that unites peripheral negative and positive selection with the maintenance of mature B cell numbers. Moreover, it implies a developmentally regulated coupling of BCR and BAFF receptors at the transitional stages and beyond.

引用

页码：158 / 161

页数：4

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