Bioinspired Multifunctional Black Phosphorus Hydrogel with Antibacterial and Antioxidant Properties: A Stepwise Countermeasure for Diabetic Skin Wound Healing

被引：145

作者：

Ding, Qiuyue ^{[1
]}

Sun, Tingfang ^{[1
]}

Su, Weijie ^{[1
]}

Jing, Xirui ^{[1
]}

Ye, Bing ^{[1
]}

Su, Yanlin ^{[1
]}

Zeng, Lian ^{[1
]}

Qu, Yanzhen ^{[1
]}

Yang, Xu ^{[2
]}

Wu, Yuzhou ^{[3
]}

Luo, Zhiqiang ^{[4
]}

Guo, Xiaodong ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Orthoped, Wuhan 430022, Peoples R China

[2] Hubei Univ Med, Suizhou Hosp, Dept Orthoped, Suizhou 441300, Hubei, Peoples R China

[3] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Hubei Key Lab Bioinorgan Chem & Mat Med, Wuhan 430074, Peoples R China

[4] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Peoples R China

来源：

ADVANCED HEALTHCARE MATERIALS | 2022年 / 11卷 / 12期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

4-octyl itaconate; black phosphorus; diabetic skin ulcers; photodynamic therapy; photothermal therapy; METABOLITE; ITACONATE;

D O I：

10.1002/adhm.202102791

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Cutaneous wound healing, especially diabetic wound healing, is a common clinical challenge. Reactive oxygen species (ROS) and bacterial infection are two major detrimental states that induce oxidative stress and inflammatory responses and impede angiogenesis and wound healing. A derivative of the metabolite itaconate, 4-octyl itaconate (4OI) has attracted increasing research interest in recent years due to its antioxidant and anti-inflammatory properties. In this study, 4OI-modified black phosphorus (BP) nanosheets are incorporated into a photosensitive, multifunctional gelatin methacrylamide hydrogel to produce a new photothermal therapy (PTT) and photodynamic therapy (PDT) system with antibacterial and antioxidant properties for diabetic wound regeneration. Under laser irradiation, the 4OI-BP-entrapped hydrogel enables rapid gelation, forming a membrane on wounds, and offers high PTT and PDT efficacy to eliminate bacterial infection. Without laser irradiation, BP acts as a carrier and controls the release of 4OI, with which it synergistically enhances antioxidant activity, thus alleviating excessive ROS damage to endothelial cells, promoting neovascularization, and facilitating faster diabetic wound closure. These findings indicate that 4OI-BP-entrapped multifunctional hydrogel provides a stepwise countermeasure with antibacterial and antioxidant properties for enhanced diabetic wound healing and may lead to novel therapeutic interventions for diabetic ulcers.

引用

页数：18

共 52 条

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Bioinspired Functional Black Phosphorus Electrospun Fibers Achieving Recruitment and Biomineralization for Staged Bone Regeneration [J].