Expression of APOBEC3G in kidney cells

被引：13

作者：

Komohara, Y.

Suekane, S.

Noguchi, M.

Matsuoka, K.

Yamada, A.

Itoh, K.

机构：

[1] Kurume Univ, Sch Med, Canc Vaccine Dev Div, Res Ctr Innovat Canc Therapy, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ, Sch Med, Dept Immunol, Kurume, Fukuoka 8300011, Japan

[3] Kurume Univ, Sch Med, Dept Urol, Kurume, Fukuoka 8300011, Japan

[4] Kurume Univ, Ctr 21st Century COE Program Med Sci, Kurume, Fukuoka 8300011, Japan

来源：

TISSUE ANTIGENS | 2007年 / 69卷 / 01期

关键词：

APOBEC3G; cytokine; interferon; kidney;

D O I：

10.1111/j.1399-0039.2006.00725.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a member of the APOBEC family possessing DNA mutator activity through cytosine deamination, is reported to play an important role in host defense against infections such as those of hepatitis B virus and human immunodeficiency virus. Here, we examined the expression of APOBEC3G in human kidney cells to better understand its biological role against infection. APOBEC3G was immunohistochemically detectable in kidney mesangial cells and also to some extent in kidney epithelial tubular cells. In addition, overexpression of APOBEC3G was shown in renal carcinoma tissues and cell lines. APOBEC3G expression was upregulated by inflammatory cytokines, such as interferon, interleukin-6, and tumor necrosis factor. These results may provide new insight into the role of APOBEC3G in host defense against viral infection and cancer.

引用

页码：95 / 98

页数：4

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