Intercellular adhesion molecule-1 in the heart

被引：37

作者：

Niessen, HWM

Krijnen, PAJ

Visser, CA

Meijer, CJLM

Hack, CE

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Pathol, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, ICaR, NL-1007 MB Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Dept Cardiol, NL-1007 MB Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, NL-1007 MB Amsterdam, Netherlands

[5] CLB, Sanquin Res, Dept Immunopathol, Amsterdam, Netherlands

来源：

CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS | 2002年 / 973卷

关键词：

heart; ICAM-1; acute myocardial infarction;

D O I：

10.1111/j.1749-6632.2002.tb04703.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intercellular adhesion molecule-1 (ICAM-1) belongs to the superfamily of immunoglobulin-like adhesion molecules. Up-regulation of ICAM-1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM-1-for example, in acute myocardial infarction. Moreover, inhibition of ICAM-1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM-1 may provide a novel therapeutic option for acute myocardial infarction.

引用

收藏

页码：573 / 585

页数：13

相关论文

共 98 条

[21] Platelets induce alterations of chemotactic and adhesive properties of endothelial cells mediated through an interleukin-1-dependent mechanism.: Implications for atherogenesis [J].

Gawaz, M ;

Brand, K ;

Dickfeld, T ;

Pogatsa-Murray, G ;

Page, S ;

Bogner, C ;

Koch, W ;

Schömig, A ;

Neumann, FJ .

ATHEROSCLEROSIS, 2000, 148 (01) :75-85

[22] Targeted disruption of ICAM-1, P-selectin genes improves cardiac function and survival in TNF-α transgenic mice [J].

Graciano, AL ;

Bryant, DD ;

White, DJ ;

Horton, J ;

Bowles, NE ;

Giroir, BP .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 280 (04) :H1464-H1471

[23] Up-regulation of endothelial cell binding proteins receptors for complement component C1q by inflammatory cytokines [J].

Guo, WX ;

Ghebrehiwet, B ;

Weksler, B ;

Schweitzer, K ;

Peerschke, EIB .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1999, 133 (06) :541-550

[24] Cardiac myocytes produce interleukin-6 in culture and in viable border zone of reperfused infarctions [J].

Gwechenberger, M ;

Mendoza, LH ;

Youker, KA ;

Frangogiannis, NG ;

Smith, CW ;

Michael, LH ;

Entman, ML .

CIRCULATION, 1999, 99 (04) :546-551

[25] PROTECTION OF ISCHEMIC/REPERFUSED CANINE MYOCARDIUM BY CL18/6, A MONOCLONAL-ANTIBODY TO ADHESION MOLECULE ICAM-1 [J].

HARTMAN, JC ;

ANDERSON, DC ;

WILTSE, AL ;

LANE, CL ;

ROSENBLOOM, CL ;

MANNING, AM ;

HUMPHREY, WR ;

WALL, TM ;

SHEBUSKI, RJ .

CARDIOVASCULAR RESEARCH, 1995, 30 (01) :47-54

[26] NHE and ICAM-1 expression in hypoxic/reoxygenated coronary microvascular endothelial cells [J].

Hattori, R ;

Otani, H ;

Moriguchi, Y ;

Matsubara, H ;

Yamamura, T ;

Nakao, Y ;

Omiya, H ;

Osako, M ;

Imamura, H .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 280 (06) :H2796-H2803

[27]

Hattori Y, 1997, BIOCHEM MOL BIOL INT, V41, P979

[28]

Haught WH, 1996, AM HEART J, V132, P1

[29]

Hawkins HK, 1996, AM J PATHOL, V148, P1957

[30] ICAM-1 expression on cardiac myocytes and aortic endothelial cells via their specific endothelin receptor subtype [J].

Hayasaki, Y ;

Nakajima, M ;

Kitano, Y ;

Iwasaki, T ;

Shimamura, T ;

Iwaki, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 229 (03) :817-824

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