Intercellular adhesion molecule-1 in the heart

被引：37

作者：

Niessen, HWM

Krijnen, PAJ

Visser, CA

Meijer, CJLM

Hack, CE

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Pathol, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, ICaR, NL-1007 MB Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Dept Cardiol, NL-1007 MB Amsterdam, Netherlands

[4] Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, NL-1007 MB Amsterdam, Netherlands

[5] CLB, Sanquin Res, Dept Immunopathol, Amsterdam, Netherlands

来源：

CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS | 2002年 / 973卷

关键词：

heart; ICAM-1; acute myocardial infarction;

D O I：

10.1111/j.1749-6632.2002.tb04703.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intercellular adhesion molecule-1 (ICAM-1) belongs to the superfamily of immunoglobulin-like adhesion molecules. Up-regulation of ICAM-1 occurs in many different pathophysiological processes. Also, cardiomyocytes can express ICAM-1-for example, in acute myocardial infarction. Moreover, inhibition of ICAM-1 expression in the heart dramatically reduces infarct size. Hence, inhibitors of ICAM-1 may provide a novel therapeutic option for acute myocardial infarction.

引用

页码：573 / 585

页数：13

共 98 条

[51] New indices of ischemic heart disease and aging: Studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease [J].