Calixarene HPLC phases - Applications

被引：37

作者：

Meyer, Ruediger ^{[1
]}

Jira, Thomas ^{[1
]}

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Inst Pharm Pharmaceut Med Chem, FL Jahn Str 17, D-17489 Greifswald, Germany

来源：

CURRENT ANALYTICAL CHEMISTRY | 2007年 / 3卷 / 02期

关键词：

calixarene-bonded stationary phases; HPLC;

D O I：

10.2174/157341107780361736

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Calixarenes, following cyclodextrines and crown ethers, are the third generation of supramolecules used in HPLC as stationary phases. They consist of phenol units linked via methylene bridges and can also form inclusion complexes like the other host supramolecules. The resulting interactions influence the retention factors and improve the selectivity of the solutes. Additionally, modification of the calixarencs, for instance by varying the ring size, substitutents. conformations and pKa values, enable a more enhanced interaction spectrum and can improve the specificity for guest molecules. The application of calixarenes in chromatography also includes medical and environmental applications, preparative chemistry as well as the rapidly developing area of supramolecular chemistry. Taking the possibilities and the growing interests of calixarenes into account, the aim of the review is to summarise the application possibilities and interactions of calixarenes as stationary phase in HPLC.

引用

页码：161 / 170

页数：10

共 123 条

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