Identification of tyrosinase inhibitors from Marrubium velutinum and Marrubium cylleneum

被引：163

作者：

Karioti, Anastasia

Protopappa, Anastasia

Megoulas, Nikolaos

Skaltsa, Helen ^{[1
]}

机构：

[1] Panepistimiopolis Zografou, Sch Pharm, Dept Pharmacognosy & Chem Nat Prod, Athens 15771, Greece

[2] Univ Athens, Dept Chem, Lab Analyt Chem, Athens 15771, Greece

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 07期

关键词：

Marrubium velutinum; M; cylleneum; tyrosinase; flavonoids; phenylethanoid glycosides; phenolic acids;

D O I：

10.1016/j.bmc.2007.01.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Tyrosinase is a key enzyme in the production of melanins in plants and animals. Forty-five secondary metabolites isolated from Marrubium velutinum and Marrubium cylleneum belonging to the classes of flavonoids, phenylethanoid glycosides, phenolic acids and lignan glycosides were screened for their inhibitory activity against mushroom tyrosinase. Flavonoids and phenylethanoid glycosides showed moderate inhibitory activity, while phenolic acids were less active than phenylethanoid glycosides, suggesting that both phenolic groups are important for the activity. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2708 / 2714

页数：7

共 38 条

[1]

Tyrosinase inhibitors from Rhododendron collettianum and their structure-activity relationship (SAR) studies [J].