Naringin and Naringenin: Their Mechanisms of Action and the Potential Anticancer Activities

被引：193

作者：

Stabrauskiene, Jolita ^{[1
]}

Kopustinskiene, Dalia M. ^{[2
]}

Lazauskas, Robertas ^{[3
]}

Bernatoniene, Jurga ^{[1
,2
]}

机构：

[1] Lithuanian Univ Hlth Sci, Med Acad, Fac Pharm, Dept Drug Technol & Social Pharm, Sukileliu Pr 13, LT-50161 Kaunas, Lithuania

[2] Lithuanian Univ Hlth Sci, Med Acad, Fac Pharm, Inst Pharmaceut Technol, Sukileliu Pr 13, LT-50161 Kaunas, Lithuania

[3] Lithuanian Univ Hlth Sci, Med Acad, Inst Physiol & Pharmacol, LT-50161 Kaunas, Lithuania

来源：

BIOMEDICINES | 2022年 / 10卷 / 07期

关键词：

naringin; naringenin; flavonoids; cancer; cellular signaling pathways; BREAST-CANCER CELLS; ANTIOXIDANT ACTIVITY; TUMOR INVASION; SUPPRESSES; INHIBITION; GROWTH; INFLAMMATION; METASTASIS; FLAVONOIDS; PATHWAYS;

D O I：

10.3390/biomedicines10071686

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Naringin and naringenin are the main bioactive polyphenols in citrus fruits, the consumption of which is beneficial for human health and has been practiced since ancient times. Numerous studies have reported these substances' antioxidant and antiandrogenic properties, as well as their ability to protect from inflammation and cancer, in various in vitro and in vivo experimental models in animals and humans. Naringin and naringenin can suppress cancer development in various body parts, alleviating the conditions of cancer patients by acting as effective alternative supplementary remedies. Their anticancer activities are pleiotropic, and they can modulate different cellular signaling pathways, suppress cytokine and growth factor production and arrest the cell cycle. In this narrative review, we discuss the effects of naringin and naringenin on inflammation, apoptosis, proliferation, angiogenesis, metastasis and invasion processes and their potential to become innovative and safe anticancer drugs.

引用

页数：16

共 103 条

[11]

Naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer SGC7901 cell line by downregulation of AKT pathway [J].