Response to influenza vaccine in people with non-protective HI antibody titers

被引：17

作者：

Baldo, Vincenzo

Baldovin, Tatjana

Floreani, Annarosa

Minuzzo, Michele

Trivello, Renzo

机构：

[1] Univ Padua, Dept Environm Med & Publ Hlth, Inst Hyg, I-35131 Padua, Italy

[2] Univ Padua, Dept Surg & Gastroenterol Sci, Padua, Italy

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2006年 / 21卷 / 11期

关键词：

antibody response; influenza; MF59; vaccine;

D O I：

10.1007/s10654-006-9071-4

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 [公共卫生与预防医学]; 120402 [社会医学与卫生事业管理];

摘要：

The purpose of the study was to determine which factors correlate directly with response to vaccination in such a group of subjects with non-protective HI antibody titers before vaccination. Two vaccines were used, a subunit virus vaccine adjuvanted with MF59 and a split virus vaccine. The analysis indicated that immunization with vaccine adjuvanted with MF59 was an independent variable for immune response against A/H3N2 (OR: 3.51; 95% CI: 1.81-6.79) and B (OR: 2.31; 95% CI: 1.37-3.89). The results suggest that antibody response to vaccine is satisfactory in elderly people previously lacking a protective antibody titer, and that the adjuvanted vaccine reveals a better immunogenicity.

引用

页码：843 / 845

页数：3

共 8 条

[1]

Comparison of serology and reactogenicity between influenza subunit vaccines and whole virus or split vaccines - A review and meta-analysis of the literature [J].