Medical THz imaging: an investigation of histo-pathological samples

被引:116
作者
Knobloch, P [1 ]
Schildknecht, C
Kleine-Ostmann, T
Koch, M
Hoffmann, S
Hofmann, M
Rehberg, E
Sperling, M
Donhuijsen, K
Hein, G
Pierz, K
机构
[1] Tech Univ Braunschweig, Inst Hochfrequenztech, D-38106 Braunschweig, Germany
[2] Ruhr Univ Bochum, Inst Werkstoffe Elektrotech, D-44780 Bochum, Germany
[3] Univ Giessen, Hals Nasen Ohren Klin, D-35392 Giessen, Germany
[4] Stadt Klinikum, Inst Pathol, D-38114 Braunschweig, Germany
[5] Phys Tech Bundesanstalt, D-38116 Braunschweig, Germany
关键词
Biological organs - Lasers - Pathology - Semiconductor materials - Tissue;
D O I
10.1088/0031-9155/47/21/327
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
We present a THz investigation of histo-pathological samples including the larynx of a pig and a human liver with metastasis, Our measurements show that different types of tissue can be clearly distinguished in THz transmission images. either within a single image or by a comparison of images obtained for different frequency windows. This leads to the problem that images obtained for different frequencies inherently have a different spatial resolution. An image obtained from two such images by a simple mathematical operation may contain artefacts. We discuss measure,, to deal with this problem. Furthermore, we investigate the possibility of improving the spatial resolution of THz images. Finally, we present a cw THz imaging system based on a photomixer and an external cavity semiconductor laser that allows for simultaneous two-mode operation. The cw system is less expensive and more compact than conventional time-domain imaging systems.
引用
收藏
页码:3875 / 3884
页数:10
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