S100 chemokines mediate bookmarking of premetastatic niches

被引：64

作者：

Rafii, Shahin ^{[1
]}

Lyden, David ^{[1
]}

机构：

[1] Howard Hughes Med Inst, Genet Med & Pediat Oncol Dept, Weill Cornell Med Coll, New York, NY 10021 USA

来源：

NATURE CELL BIOLOGY | 2006年 / 8卷 / 12期

关键词：

D O I：

10.1038/ncb1206-1321

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Primary tumours release soluble factors, including VEGF-A, TGF beta and TNF alpha, which induce expression of the chemokines S100A8 and S100A9 in the myeloid and endothelial cells within the lung before tumour metastasis. These chemokine-activated premetastatic niches support adhesion and invasion of disseminating malignant cells, thereby establishing a fertile habitat for metastatic tumours.

引用

页码：1321 / 1323

页数：4

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